Total synthesis of the core heptasaccharyl myo-inositol, Galp(a1-6)Galp(a1-3)Galf(b1-3)[Glcp(a1-PO4-6)Manp](a1-3)Manp(a1-4)GlcNp(a1-6)Ins-1-PO4, and the corresponding hexasaccharyl myo-inositol, Galp(a1-6)Galp(a1-3)Galf(b1-3)Manp(a1-3)Manp(a1-4)GlcNp(a1-6)Ins-1-PO4, found in the lipophosphoglycans of Leishmania parasites are described. The target mols. contain synthetic challenges such as an unusual internal galactofuranosyl residue and an anomeric phosphodiester. The synthesis was accomplished using a convergent block synthetic strategy. Four building blocks, a trigalactoside, a dimannoside, a glucosyl inositol phosphate, and a glucosyl-a-1-H-phosphonate, all appropriately protected, were used. The trigalactoside was linked to the dimannoside followed by glycosylation with the glucosyl inositol phosphate to produce the fully protected hexasaccharyl myo-inositol. Subsequent oxidative coupling of the glucosyl-H-phosphonate formed the anomeric phosphodiester linkage to produce the protected heptasaccharyl myo-inositol. Both the assembly order of the subunits and sequence of deprotection were essential for the successful synthesis of these complex mols. The deprotection was accomplished by deacetylation and cleavage of benzyl ethers with sodium in liq. ammonia, followed by acidic deacetalization/desilylation to produce the target mols. [on SciFinder (R)]